Late effects of total body irradiation.

Late effects of total body irradiation

Total body irradiation (TBI) is a powerful but potentially hazardous tool used in the eradication of malignant cells and the suppression of the immune system to enable bone marrow engraftment. The occasion of its use is confined to bone marrow transplantation (BMT) in malignant disorders and some non-malignant haematological and metabolic conditions and is accompanied by high dose chemotherapy....

Late effects of total body irradiation.

Late effects of chemo-radiotherapy conditioning before bone marrow transplantation (BMT) are being increasingly recognised in long-term survivors, particularly children. They can be divided into two categories: those affecting hormonal status and those affecting specific organ function. All women treated develop ovarian failure with low levels of beta-oestradiol and raised values of follicle-st...

Late effects of total body irradiation

Total body irradiation (TBI) is a powerful but potentially hazardous tool used in the eradication of malignant cells and the suppression of the immune system to enable bone marrow engraftment. The occasion of its use is confined to bone marrow transplantation (BMT) in malignant disorders and some non-malignant haematological and metabolic conditions and is accompanied by high dose chemotherapy....

Late effects of total-body roentgen irradiation. Longevity and incidence of nephrosclerosis as influenced by partial-body shielding.

Effects of methotrexate and total body irradiation on mouse lungs.

Separate and combined effects of methotrexate and total body irradiation were studied on normal lungs of mouse. Forty female albino mice weighing 25 to 30 gms were divided into five groups including that of controls. On gross inspection, 70% of lungs of combined therapy group showed signs of congestion, 10% edematous changes and 20% blackish mottling. Microscopic examination revealed marked his...